Of veiling kathoeys and bearded bois

What comes to mind when one says, Iran?

Nuclear warheads pointing westward? Bare-chested bearded men flagellating themselves down the avenue a la the best Folsom Street tradition? Xerxes and his funky curls?

I was privileged to experience first hand the beauty of the country and marvel at their historical monuments. The food is marvellous and travelling there can be pretty cheap. You get the pleasures of the four season and easy food (for Muslims).

But do many people realise that Iran is actually transsexual friendly? Apparently they lag second behind Thailand for the number of sex-change operation conducted annually. Yup, that means chopping off the family jewels and constructing a new plumbing system. Or creating new package where there wasn't any. If you want the gory details, go google it yourself.

Now, you may think ... nah ...

But seriously, the Shiite clerics are pretty enlightened about a number of things. The late Ayatollah Khomeini issued a fatwa to allow a trans-woman to undergo surgery, after asking his physicians to explain to him the difference between a hermaphrodite and a transgendered person. He believed that a good Muslim need to have a proper gender identity in order to fulfill his/her spiritual obligations and if that means going under the knife ... then so be it. Once they are the gender of preference, they are obligated to adhere to the conventions pertaining to their gender; e.g. veiling for women and beards for men.

This however, does not mean homosexuality is legal. They adhere to the strict interpretation of the Shariah law whereby men who have same-sex relations (the biblical knowing, okay?) can be sentenced to death. But a woman can marry a man who was born a woman (and vice versa).

The Government also issues a new set of documents to people who had undergone gender reassignment surgery for their new identity. So no getting flagged at the airport because the passport picture doesn't match. Isn't that wonderful?

So Fatine, hie yourself to Tehran, pronto!

Eau de body

I am sure many of you have had the experience of encountering someone who makes skunks smell heavenly. But do you know that body odour can be used against you in the court of law? Thanks to science, your body odour can be used as material evidence to implicate you in a crime.

The lesson of the day: use deodorant.

Why Jimmy Choos are lusted over more than Hugh Jackman

It seems that a pair of shoes is more memorable than an ex-boyfriend.

Interesting finding, that. But knowing women and their ability to prioritise, I am not surprised. A good pair of shoes last a long time and keeps you comfortable on long journeys. An aggravating ex-boyfriend? Just a pain in the ass.

How to live with a hole in your soul (or torso)

Ganked in its entirety from Medscape. But it is sooooo fun and gruesome and the not-so-little geek in me just wanted to have a show and tell.

From Medscape General Surgery > Historical Perspectives in Surgery

The Case of the Wounded Woodsman and His Dedicated Physician

Albert B. Lowenfels, MD

Published: 09/02/2009

The Case

The patient was a 28-year-old, healthy itinerant laborer who was accidentally shot at close range by a companion. The shell entered the left anterolateral side of his body a few inches below the left nipple. The patient fell to the ground but remained conscious. A physician who examined the patient shortly after the accident noted a large wound of entry about the size of a man's hand, but no wound of exit. The left lung protruded through the opening along with a portion of the stomach, with an opening caused by the bullet. Several adjacent ribs had been fractured. Food from a recent meal was present in the wound.

In describing the patient's injury, his physician wrote: "I considered any attempt to save his life entirely useless." Nevertheless, his physician debrided the wound, replaced the protruding stomach and lung, and applied a protective dressing. On the following day, the patient developed fever, a cough, and had evidence of pneumonia. For the next week, the patient continued to be febrile; the wound became infected; and the patient was fed rectally.

To the physician's surprise, over the next several weeks the patient's condition gradually improved, although the gastric wound never completely closed. Nevertheless, he could tolerate oral feedings if the gastric opening was occluded with a compressive dressing. Over the next year, the patient's strength gradually returned to normal, but the gastric wound refused to close. The physician made an arrangement with the patient to follow him more closely and to study his gastric physiology; these studies continued intermittently over the course of many years.

Who was the patient?

Daniel Boone

Kit Carson

Alexis St. Martin

Paul Bunyon

Who was the physician?

William Osler

William Beaumont

Harvey Cushing

William Wells

Brief History of the Physician and His Patient

William Beaumont (1785-1853) was born into a farming family and grew up in Connecticut, where he remained until his early 20s when he joined his brother in Upstate New York.^[1] There, he taught school for several years, before deciding at the age of 25 to study medicine. Although it was possible in the early 19th century to practice medicine without any formal training, Beaumont became an apprentice to Dr. Benjamin Chandler, a prominent Vermont physician. This apprenticeship lasted for 1 year, covered both medicine and surgery, and led to certification by the Vermont Medical Society. His training never included any formal background in physiology, and it is unlikely that Beaumont was aware of the available rudimentary knowledge of gastrointestinal physiology.

Figure 1. Portrait of William Beaumont, frontier doctor and scientist.
From Gillett MC. Early campaigns in the North, 1812 to 1813. In: Matloff M, ed. The Army Medical Department 1775-1818. Army Historical Series. Available at: http://history.amedd.army.mil/booksdocs/rev/gillett1 Accessed August 26, 2009

In 1812, a few months after receiving his certification, Beaumont enlisted in the US Army, and then actively engaged in war with the British Empire. Eventually, after the conclusion of the War of 1812, Beaumont was posted to Fort Mackinac, an important trading post located on a small, remote island between Lake Huron and Lake Michigan.

By good fortune, Beaumont was at the Fort on June 6, 1822, when Alexis St. Martin, a French-Canadian employee of the American Fur Company, was accidentally shot in the left chest. Beaumont had received some surgical training during his apprenticeship and additional experience while caring for injured soldiers during the War of 1812. Without Beaumont's presence, it is unlikely that St. Martin would have survived such a serious injury.

St. Martin came from a background that was very different from Beaumont's. According to his birth certificate, St. Martin was born in 1794, in the small Canadian village of Berthier. His family, who originated from Bayonne, France, was poor, and St. Martin grew up to be an illiterate trapper. He earned his living as a fur trader and voyageur (a porter and large cargo canoe man) in the region between what is now Michigan and Canada. When he was wounded, St. Martin was 28 years old and unmarried.

When St. Martin was sufficiently recovered, he signed a contract with Beaumont, who offered him employment as a handyman in return for a stipend, food, and permission to carry out experiments on St. Martin's stomach. To facilitate the research, and to ease the financial burden on the physician, the US Army made St. Martin a sergeant, paying him a small salary.

About a year after St. Martin's injury, when Beaumont realized that the gastric wound was unlikely to close, he began detailed studies of the process of digestion within St. Martin's stomach. These experiments, conducted with the often reluctant St. Martin, continued intermittently over the course of about a decade. St. Martin agreed to travel to Europe to be examined and studied by leading physicians, including Claude Bernard, but he changed his mind before embarking on the voyage. He never did go to Europe, but he did exhibit his fistula at several American medical schools.

Despite Beaumont's efforts, the wound never completely healed; nevertheless, St. Martin was able to resume a nearly normal life if he plugged up the gastric opening with a piece of cloth. Eventually St. Martin married and had several children. He was always poor, however, and frequently drunk. His health, despite the fistula, was sufficiently robust so that he could support his family by hard labor, such as chopping wood.

Regardless of his persistent gastric fistula and his heavy consumption of alcohol, St. Martin lived to be 86 years old; even now this is well above the normal life span for white men in North America. As for Beaumont, after completing his army service, he settled in St. Louis, Missouri, where he practiced medicine until he died in 1853 from a head injury after falling on an icy path. St. Martin outlived his physician by several decades.

Prior to St. Martin's death, prominent physicians, including William Osler, had tried without success to persuade the family and the patient to agree to an autopsy.^[2] Osler was particularly anxious to examine St. Martin's famous stomach and to have it preserved in the US Army Museum. However, the family was vehemently opposed to any further contacts with the medical profession. To ensure that his body would not be disturbed, the family buried St. Martin in an unmarked deep grave. Only in 1962, more than 80 years after his death, did the Canadian Physiological Society place a marker at the approximate grave site.

What Beaumont Added to the Knowledge of Gastric Physiology

Before Beaumont's long-term observation of St. Martin's progress, other patients had sustained gastric wounds and lived with a gastric fistula, but none had been studied in a scientific fashion.^[3] Toward the end of the 18th century, the Italian Lazaro Spallanzini conducted a series of experiments and concluded that the stomach contained an active principle and that digestion was more than a simple mechanical process. In 1803, Jacob Helm, a Viennese physician, studied a middle-aged woman with a gastric fistula, noting the ability of the gastric juice to act upon stomach content. Just prior to Beaumont's first publication, an English chemist, William Prout, noted that the stomach secreted hydrochloric acid.^[4] It is unlikely that Beaumont knew about any of this work on the stomach: His observations are unique.

Without any formal training in physiology, gastroenterology, or any branch of science, Beaumont recognized a unique opportunity, and over the course of several years he performed numerous experiments that led to a solid foundation for gastric physiology. The astonishing aspect of Beaumont's research is that under difficult circumstances he took advantage of a rare chance to study digestion by visualizing the interior of the stomach and obtaining samples of gastric juice from a living subject under various circumstances. Moreover, he took careful, detailed notes.

Beaumont performed a series of 3 experiments on St. Martin at geographic locations separated by thousands of miles.

Figure 2. Map listing locations and dates for major events in the lives of St. Martin and Beaumont.

The experiments were carried out under less than ideal circumstances on a patient who was not always cooperative. Today, it would be difficult to obtain approval to perform a similar series of experiments. Beaumont describes his first experiment as follows^[5]:

EXPERIMENT 1. August 1. 1825 -- At 12 o'clock, A.M., I introduced through the perforation, into the stomach, the following articles of diet, suspended by a silk string, and fastened at proper distances, so as to pass in without pain -- viz.: -- a piece of high seasoned la mode beef, a piece of raw salted fat pork, a piece of raw salted lean beef, a piece of boiled salted beef, a piece of [unclear] bread, and a bunch of raw sliced cabbage; each piece weighing about two drachms, the lad continuing his usual employment about the house. At 1 o'clock, PM, withdrew and examined them -- found the cabbage and bread about half digested; the pieces of meat unchanged. Returned them into the stomach. At 2 o'clock, PM withdrew them again -- found the cabbage, bread, pork, and boiled beef, all cleanly digested,* and gone from the string...The lad complaining of considerable distress and uneasiness at the stomach, general debility and lassitude, with some pain in his head, I withdrew the string, and found the remaining portions of aliment nearly in the same condition as when last examined; the fluid more rancid and sharp...I did not return them any more.

*These experiments are inserted here, as they were originally taken down in my note-book....

Beaumont published his early results in January 1825, after his first series of experiments and about 3.5 years after St. Martin's injury.

His major contributions to our knowledge of the digestive process included:

• Studies of gastric motility;
• Studies of gastric acidity (recognition of the importance of hydrochloric acid);
• An important role for neurogenic influences on digestion, which eventually led to vagotomy as a treatment for peptic ulcer disease; and
• A suspicion that something other than acid accounted for the stomach's ability to digest food.

Of note, this last substance turned out to be pepsin, which was eventually identified by Theodore Schwan in 1836, shortly after Beaumont concluded his third series of experiments.

How Would the Patient's Wound Be Treated Today?

St. Martin sustained the full force of a shotgun blast fired accidentally at close range, resulting in a complex wound involving the left lung, the stomach, and the diaphragm. Beaumont describes a "fist-sized" hole (approximately 9 x 9 cm) in the left lateral chest wall. St. Martin apparently remained hemodynamically stable after his injury, although the sphygmomanometer wasn't invented for several more decades -- so there were no blood pressure measurements.

Figure 3. Beaumont's sketch of St. Martin's wound about 4-6 weeks after the injury.
From Beaumont W.⁵

Even today, this injury would present a significant challenge to a surgeon.^[6,7] However, long-term results following current surgical repair of severe chest wall injuries are excellent, with patient status being similar to the general population.^[8] Current management would include the following:

• Careful physical examination supplemented by imaging studies to determine the extent of injury.
• If there were a pneumothorax or respiratory compromise following this chest wound, ventilatory support would be provided via an endotracheal tube until the patient was ready for surgery. (Note: there was no mention of shortness of breath from a pneumothorax in St. Martin's case.)
• Exploration via a left thoracoabdominal incision.
• Careful exploration to ensure that no other organs, such as the pancreas or the spleen, had been injured.
• Debridement and cleansing of the original wound to remove shattered rib fragments, necrotic lung tissue, imbedded clothing, fragments of the shell, and food particles.
• Blood transfusion, rather than bloodletting, as was done for St. Martin.
• Closure of the gastric wound and the diaphragmatic tear.
• Repair of the chest wall defect. This would probably require application of a synthetic mesh covered by a muscle flap. If necessary, the repair in the chest wall could be closed with a split-thickness skin graft.

Summary

By a fortunate coincidence, William Beaumont -- a young, resourceful, relatively inexperienced US Army surgeon -- happened to be stationed in a remote fort on the western frontier of the United States when Alexis St. Martin, a French-Canadian voyager, received a near-fatal gunshot wound of the chest. St. Martin survived, but was left with a permanent gastric fistula, permitting Beaumont to perform a series of unique experiments that greatly expanded our knowledge of gastric physiology.

Traditionally, St. Martin's physician has received full recognition for the brilliant series of experiments carried out under primitive conditions. However, St. Martin also should be credited for participating in tedious, repetitive experiments that must have been disagreeable and sometimes painful.^[9] Although not always cooperative, he should be remembered as being perhaps the first of that special group of human "guinea pigs" who have done so much to advance the progress of medicine. Two centuries later, physicians and patients remain indebted to Beaumont and Alexis St. Martin -- Beaumont's often reluctant patient.

Additional Reading

• Green AH. The Market Cultures of William Beaumont: Ethics, Science and Medicine in Antebellum America, 1820-1865 [doctoral thesis]. Baltimore: The Johns Hopkins University; 2007. AAT 3262421.

Internet Sources

• Helms R. Alexis St. Martin (1794-1880): the intrepid guinea pig of the Great Lakes. Available at: http://www.guineapigzero.com/AlexisStMartin.html Accessed August 20, 2009.
• Life of Dr. William Beaumont. Available at: http://www.james.com/beaumont/dr_life.htm Accessed August 20, 2009.

Museums

• American Fur Company Store and Dr. Beaumont Museum. Available at: http://www.mackinacparks.com/ Accessed August 26, 2009.
• Prairie du Chien Museum at Fort Crawford. Available at: www.fortcrawfordmuseum.com Accessed August 26, 2009.
• William Beaumont Birthplace. Available at: http://www.james.com/beaumont/dr_birthplace.htm Accessed August 26, 2009.

References

1. Horsman KR. Frontier Doctor. William Beaumont, America's First Great Medical Scientist. Columbia, Mo: University of Missouri Press; 1996.
2. Sarr MG, Bass P, Woodward E. The famous gastrocutaneous fistula of Alexis St. Martin. Dig Dis Sci. 1991;36:1345-1347. Abstract
3. Modlin IM. From Prout to the proton pump -- a history of the science of gastric acid secretion and the surgery of peptic ulcer. Surg Gynecol Obstet. 1990;170:81-96. Abstract
4. Rosenfeld L. William Prout: early 19th century physician-chemist. Clin Chem. 2003;49:699-705. Abstract
5. Beaumont W. Experiments and Observations on the Gastric Juice and the Physiology of Digestion. Mineola, New York: Dover Publications, Inc.; 1959. Available at: http://books.google.com/books?id=H6F4_9joRkgC&pg=PA8&dq Accessed August 20, 2009.
6. Koch H, Tomaselli F, Pierer G, et al. Thoracic wall reconstruction using both portions of the latissimus dorsi previously divided in the course of posterolateral thoracotomy. Eur J Cardiothoracic Surg. 2002;21:874-878.
7. Weyant MJ, Bains MS, Venkatraman E, et al. Results of chest wall resection and reconstruction with and without rigid prosthesis. Ann Thorac Surg. 2006;81:279-285. Abstract
8. Mayberry JC, Kroeker AD, Ham B, Mullins RJ, Trunkey DD. Long-term morbidity, pain, and disability after repair of severe chest wall injuries. Am Surg. 2009;75:389-394. Abstract
9. Myers NA, Durham-Smith E. A debt to Alexis: the Beaumont-St Martin story. Aust N Z J Surg. 1997;67:534-539. Abstract

Authors and Disclosures

Author(s)

Albert B. Lowenfels, MD

Professor of Surgery, Professor of Community Preventive Medicine, New York Medical Center, Valhalla, New York; Emeritus Surgeon, Department of Surgery, Westchester Medical Center, Valhalla, New York

Disclosure: Albert B. Lowenfels, MD, has disclosed that he has served on an advisor to Solvay Pharmaceuticals Inc.

Medscape General Surgery © 2009 Medscape, LLC

The many sources of aurgasm

A number of my friends have fallen victim to my blathering on and on and on about music; usually over artists / music genre that they never heard before or care about. *grin* You could recognise them after the fact of my bending their unwilling ears by the glazed look in their eyes and the discreet drool slowly dripping off their chin.

Tonight, I was introduced to a new source of aurgasms: qasidah. It is a form of poetry that is paired with melody and beat, recited in honour of some special personage. In Malaysia, it is commonly sung as tribute to the Prophet Muhammad, PBUH, at weddings, cukur jambul and other ceremonies with a strong religious overtones (which is many for Malays).

The group Al-Kawakib presented three qasidah tonight at the 51st Al-Quran Recitation Assembly at the Putra World Trade Centre. I saw parts of it on live telecast, courtesy of TV1, with one part interrupted by a remote control battle with my niece. I'm proud to say that tonight? I won. The qasidah was part of the performance during the break before the rest of the qari and qariah presented their recital in the second half.

There were roughly 12 men in the group, with three in the last row with hand drums to keep the beat. Their ages range from early twenties to late fifties. There were four lead singers lauding praise to the Prophet Muhammad, PBUH, with the rest either keeping beat or backup harmonies. Each singer had a red-bound song book placed on rehal (an instrument to support the Al-Quran when reading on the floor, commonly made of wood) placed before them; they appeared to be handwritten. The beautiful melding of tenor and baritone brought tears to my eyes, their voices resonating with love and devotion.

For a song to capture me, it need not even be in a language I understand. It is all about the melody and the emotions expressed in the voice that moves you. I have cried listening to flamenco songs; for all I know, they were singing about losing their goats in the Pyrenees. But the mournfulness of the song was unmistakable, tugging at the beating organ behind my sternum. Sigh. I am such a sap.

The power of emotion relayed through voice cannot be underplayed. To many ears, the recital by the qariah from Kazakhstan was rather flat and monotonous; she had no flourishes or rills common to most qaris. To me however, her recital was heartfelt; I thought that her approach suited the surah she was reading wonderfully. She recited Al-Hadid from verse 20 onwards and if you read the meaning, you'll understand what I mean. The clear, bell-like tones of her voice was simply wonderful to my ears. Her purity of note brought to mind the silky flutes of 60s instrumental songs that always made me think of a really good acid trip. Okay, perhaps the comparison was not apt, but I think you know what I mean.

Perhaps I can win the remote control war again tomorrow night. I need my daily dose of aurgam.

*grin*

Weavers and hunters

People's reaction to spiders are commonly primal: scream and run or scream and kill. Thankfully, I have never encountered (and God please may I never) spiders of such an awesome specimen as this (read the comments, it is worth your time). I would probably just stare at it and just ... stare. However, if I were this guy, I may adopt a different approach.

Perhaps along the lines buying an airline ticket and getting the hell out of Dodge. Or Japan as it seems.

*shudder*

Wallowing in auditory bliss ...

Mary Kay and I went to Hujan's Rainger's Gathering at the Itudio Studio at Kelana Mall today. Lyn joined us there. Gotta say it was a lovely surprise to have a jam session begin with prayers of thanksgiving. Apparently it was the band's tribute to their loyal fans for their support for the past three years; allowing them to grow and go places.

I first heard of them while watching the television series Kami on 8TV; stumbled across the show by accident while I was ironing. It was intriguing with a gritty realism that is largely absent in most Malay dramas; the story was reflective of the realities facing urban and suburban teenagers (i.e. drugs, truancy, isolation, angst, family trouble, friends, love, music etc).

Gotta say that their energy and verve is really something. They sound better live than on radio, unlike a number of the Akademi Fantasia product. Their songs are catchy, lyrical and poetic, capturing the their thoughts on issues ranging from heartbreak, loss, social musings and political headlines. I was bopping my feet and head along; the crowd was very restrained, doing anything more would be inappropriate.

I was humbled by the fantastic opportunity for me to experience Malaysian indie music at its finest. It is also delightful to know that their fame hadn't blinded them to other struggling bands and fellow artistes who are working to make their name and work known. Stormbay (?), one of the guest acts, acknowledged that Noh helped them gain exposure by telling the producer of Remaja, a show on TV3 to give them a chance. Near all of the guest acts have a story to tell regarding how the Hujan members have helped them out one way or another.

Have a listen. Enjoy.

Miserly emotions not required

We would all love to be the first and only love of someone's life. And hopefully, we feel the same way about our partner.

This woman, however, had the courage to be the second love of her husband's life. Her generosity of spirit and love is humbling. She's no saint and I'm sure many a wife would identify with her exasperation at her husband's inability to score his clothes in the laundry hamper. Her wry acknowledgment that she may fare poorly in comparison to his first wife resonates with honesty and an expansiveness of spirit.

Ah, vive l'amour ...

Learning from the animal kingdom ... NOT!!!!

We humans like to think that we are special. But there is a group of people who believe that humans are no better than animals and as such, all creatures should be treated equal. If you want to give paid maternity leave to your cat or your seat on the LRT (light rail transit) to the visiting hippopotamus, be my guest.

But as human beings, we are held accountable by a different set of rules, yes? You may say that homosexuality is natural, but if a human being had done what this male duck did, he would be imprisoned. With a straitjacket over his prison uniform.

Apparently, it took Dr Moeliker over five years to gather up courage to report the necrophiliac homosexual rape of a male mallard (fancy name for duck) outside his office. Love how deadpan and wry his writing is (it is something I don't see in the journals I usually read, darn those dry, snooze generating stuff) and it is reflected in his presentation (see below a video presentation of Dr Moeliker on the occasion of receiving his IgNobel Prize).



Guys, I won't blame you if you feel a little inadequate; the rapist duck clocked in at 75 minutes thrust time and only stopped after the estimable Dr Moeliker interrupted his business. In between, he had rested only twice, each time lasting less than five minutes.

Sexual harrassment also exist in the animal kingdom. South African biologist Nico de Bruyn reported of an Antarctic fur seal who had (mistakenly?) mounted an adult king penguin (of unknown sex) for 45 minutes. Golly, there is just no escaping jerks like that, huh?

Adding to a growing vocabulary ...

Came across a new word today: figjam.

It is an acronym for F*** I'm Good Just Ask Me. Applicable to narcissistic types who think that the world revolves around them, that they can do no wrong, it is always the other person's fault etc etc etc. I'm sure you've met this type before. If you have to work with one of them, God help you and you have my sympathies.

Just glad that I don't have an opportunity to label anyone with this today. Go, me.

What to do when the villagers come knocking with pitchforks and torches ...

If you are about to be flambeed for some screw ups of your organisation, do not panic. It is not the end of the world, although you could feel the noose tightening and the horse beneath you bucking. All you need to do is go to "Dealing with an Angry Public", a Program on Negotiation offered by Harvard Law School.

I guess the PR people of the giant automobile corporations and failing banks the world over should go for it. It offers to help you communicate effectively when you are, "Confronted by the need to take effective action in the face of public anger (e.g., over a devastating accident, the failure to regulate products or services adequately, or the siting of a controversial facility)".

Endorsed by many. Look at some testimonials below.

“A great program! I’m walking away with a principled approach to deal with an angry
public.”
Col. Boykin Jordan, Jr., Commander, 55th Communication Group,
U.S. Air Force

“ . . . more than thinking ‘outside the box’. You learn to stand on top of the box.”
Brian Hague, Communications Director,
County of Bergen, NJ

Perhaps then you won't have to worry about being lynched (or at the very least, tarred and feathered) by the angry mob.

Pride Without Prejudice

Well, apparently denial/The Nile is not merely a river in Egypt; it is also a coping mechanism.

Go figure.

A Little Less Conversation

Tagged by Sweet Eve. Hee!

The rules:
1. Put your music on shuffle.
2. For each question, press the next button to get your answer.
3. YOU MUST WRITE THAT SONG NAME DOWN NO MATTER HOW SILLY IT SOUNDS!
4. NO CHEATING! (yeah, right)
5. Tag others (only if you wanna)


IF SOMEONE SAYS “IS THIS OKAY” YOU SAY?
Help Me I'm Falling in Love (Again) (kd lang)

WHAT WOULD BEST DESCRIBE YOUR PERSONALITY?
Make it Mine (Jason Mraz) ..... Covetous we are, precious ....

HOW DO YOU FEEL TODAY?
Run Baby Run (Sheryl Crow) ..... the hell? my ankle hurts!

WHAT IS YOUR MOTTO?
Never Miss a Beat (Kaiser Chief) ..... Well, since it is the anthem of every ignorant git of an adolescent boy ... yeah. This is right.

WHAT IS YOUR LIFE’S PURPOSE?
Your Body is a Wonderland (John Mayer) .....Oh yez...

WHAT DO YOUR FRIENDS THINK OF YOU?
A Pain that I'm Used To (Depeche Mode) ..... Gee, and I thought we're pals ...

WHAT DO YOU THINK ABOUT VERY OFTEN?
Bad Case of Loving You (Doctor, Doctor) (Robert Palmer) ..... Will it never be out of my mind? *snerk*

WHAT IS 2+2?
Time is On My Side (Rolling Stones) ... I flunked add maths, though I adore Numb3rs.

WHAT DO YOU THINK OF YOUR BEST FRIEND?
I'll Remember (Madonna) ..... Will store all our shananigans together, yup ...

WHAT DO YOU THINK OF THE PERSON YOU LIKE?
Take a Bow (Madonna)

WHAT IS YOUR LIFE STORY?
Carbon (Tori Amos) ..... Need to plant a tree to offset ... or maybe a forest.

WHAT DO YOU WANT TO BE WHEN YOU GROW UP?
Addicted to Love (Robert Palmer) ..... Yez! Wants ...

WHAT WILL THEY PLAY AT YOUR FUNERAL?
Paint it Black (Rolling Stone) ..... and then eat, drink and be merry ...

WHAT WILL YOU DANCE TO AT YOUR WEDDING?
Dreams (Fleetwood Mac) ..... kinda bittersweet, no?

WHAT DO YOU THINK WHEN YOU SEE THE PERSON YOU LIKE?
3.45 No Sleep (The Cardigans) ..... Your snoring ... *smirks*

WHAT IS YOUR HOBBY/INTEREST?
You'll See (Madonna) ..... You know what it is ...

WHAT IS YOUR BIGGEST SECRET?
Jesus Doesn't Love Me Anymore (Dragonette) ..... how appropriate...

WHAT DO YOU THINK OF YOUR FRIENDS?
All I Wanna Do (Sheryl Crow) .....Yez! Let's go! *wink wink*

WHAT’S THE WORST THING THAT COULD HAPPEN?
Sweet Sangria (Tori Amos) .....the need to drown one's sorrow...

WHAT MAKES YOU CRY?
Your Cloud (Tori Amos) ..... this song really does... sweet and a little melancholic ...

WHAT MAKES YOU LAUGH?
Don't Stop Me Now (Queen) ..... belting this out with Freddy at 100 km an hour ...

WHAT IS THE ONE THING YOU REGRET?
And I Love Her (The Beatles) ... that I should be omnivorous?

HOW WILL YOU DIE?
Pour Some Sugar On Me (Def Leppard) ..... what a way to go!...

WILL YOU EVER GET MARRIED?
Girl, You'll Be a Woman Soon (Urge Overkill) ..... Hee! you tell me ...

WHAT DO YOUR PARENTS THINK OF YOU?
Scarlet's Walk (Tori Amos) .....pretty true considering the path I tread ...

DOES ANYONE LIKE YOU?
Landslide (Fleetwood Mac) .. uh ...

WHAT SCARES YOU THE MOST?
A Place Called Home (Kim Richey) ..... the fear of hurting the nearest and dearest to me ...

IF YOU COULD GO BACK IN TIME, WHAT WOULD YOU CHANGE?
Heads Will Roll (Marion Raven) ..... ver royal like, what?...

WHAT WOULD YOU SAY, WHEN YOU MEET YOUR BOSS?
I'm Going Slightly Mad (Queen) ..... Literally.

WHAT WILL YOU POST THIS AS?
A Little Less Conversation (Elvis Presley) .. it's all about the aurgasm, baby!

The Dadiator

Man, you gotta take your hat off to this guy. Having seven kids in the space of five years is one thing, but making them work into not giving into the middle age spread? Whew.

Wonder if my niece would mine being part of my exercise equipment.

Malaria Destructo: Anti Retroviral Drug Goes Mediaeval on Plasmodium's @ss

Snagged from Medscape. Hoo wee! Good news in the face of rising resistance to artermisinin-based chemotherapy.

NEW YORK (Reuters Health) Jan 22 - Protease inhibitors, already valued in treating HIV infection and under investigation as anti-protozoals and anti-cancer agents, now demonstrate new potential as anti-malaria drugs.

A laboratory study by U.S. researchers has shown for the first time that HIV protease inhibitors inhibited the development of preerythrocytic-stage plasmodium parasites. Lopinavir and saquinavir separately had this effect in vitro, and the combination of lopinavir and ritonavir had this effect in mice. The study was published in the January 1 issue of The Journal of Infectious Diseases.

These data are important, "as there is currently no clinically available drug that has an effect on the liver stages in the way that we have demonstrated HIV protease inhibitors have an effect," Dr. Charlotte V. Hobbs of New York University School of Medicine told Reuters Health. "HIV proteases inhibitors are unique in their demonstrated ability to inhibit parasite development in the liver stages, at which point the parasite is initially present in much lower numbers."

Since 2004, published research has shown that HIV protease inhibitors can be effective against plasmodium in the erythrocytic stages of the protozoan's life cycle.

The current researchers found that saquinavir and lopinavir inhibited the development of Plasmodium berghei exo-erythrocytic forms in vitro, but that atazanavir, amprenavir and nelfinavir did not.

In the in vivo part of the study, which used P. yoelii, lopinavir/ritonavir exerted a dose-dependent effect in reducing the burden of liver-stage parasites in mice, while saquinavir alone had no effect, even at high doses.

Dr. Hobbs told Reuters Health that although theories have been proposed, no one knows the exact mechanism by which HIV protease inhibitors affect malaria parasites. "If one could elucidate this mechanism," she said, "one could perhaps develop a further class of antimalarial drugs based on the chemical structure of an HIV protease inhibitor.

J Infect Dis 2009;199:134-141.

Year of Science 2009

In celebration Charles Darwin's 2nd centennial bash, more than 150 scientific organisations (predominantly in the United States) had declared 2009 as the Year of Science. So here is the website, hosted by the Lawrence Livermore National Laboratory.

Go look. Explore. Enjoy.

Living with a Lab Rat

As I dip my toes into looking at human subjects, it became clearer to me how hard it is to recruit subjects who not only fits the criteria you wish, but also those who would agree to be poked/prodded/electrocuted etc.

I got the link to this article in NYTimes from The Scientist' Community and when I started reading, I thought, "Hey, why not?" My cousin who was working on juvenile immune response recruited her nieces and nephews for her study. She bribed them to agreeing to come with her to the hospital to have their blood drawn. To date, there don't seem to be any kind of negative effect from their participation in her Master's project.

In general, children have an innate desire to please the adults in their life; be it a parental figure or any other caretaker. Is their consent for the study something taken for granted or is easily waived away because their parent(s) signed the parental consent form? What happens when they grew up and decided that they were not happy with having participated in the study and wishes for the data to be withdrawn? That is something that have been seen in adult participants who withdrew from studies.

I wonder if any of the children who participated in their parent(s)' studies have ever said something along the lines of, "Hey, my data helped you get that professorship. How about springing a car/Playstation/new dress etc for me?"

*ponders*

At the Frontline of Healthcare

If you join the armed forces or the police department, you are expected to be exposed to assaults and other bodily harm in the course of your job. But evidently, nursing is another job whereby not only are you subjected to verbal abuse, you may expect to go home with a broken nose or worse.

Boy, oh boy.

Standing on the Shoulder of Giants

No one learns in isolation. Even the best philosophers get illuminated by watching and learning the world around them. And when you are a dunce, it is very important to learn from someone who knows. When I came across this link, I nearly wept in gratitude.

For the past few weeks, I've been struggling to re-educate myself with matters of molecular biology and genetics with hopes of making a go of my pharmacogenetics project. As a person who is an audio-visual learner, looking for the right medium to get your wheels going can be a right pain. And isn't it fantastic that the world is populated by kind people who are generous with their knowledge?

Thank you so much Drs. Tyra Wolfsberg, Kris Wetterstrand, Mark Guyer, Francis Collins and Andreas Baxevanis.

*dances with joy at the marvel of the Interwebs*

Taking the Joy Out of Watching Mindless Violence

I have always enjoyed action movies; the more gory the mindless violence the better. Explosive stuff aplenty? I'll be there with bells on. You never really think about the gun stances that the actors take and I'll bet a lot of people thought those things can and really do happen.

Chuck Dixon very kindly disabused me of those notions in his post here. Now the next time I watch something with gratuitous gun violence, all these details will pop into my head and take me out of the story.

*facepalm*