Wednesday, February 3, 2010

Standing on the shoulder of giants

We learn from one another and build upon each other. This is never more true than in the medical sciences where hideous tests on prisoners of wars translated into hypothermia treatment and understanding the process of wound healing.

Radical bioinformatics that will make all experiments in silico is still some time away, so scientists who want to study biological processes but don't work with live animals (either in vivo or in situ) commonly use tissue culture from derived cell lines. The most famous of which are the HeLa cells that was derived from the tumours that riddled Mrs. Henrietta Lacks, an African American woman who died of cancer in 1951.


The thing was, permission was not obtained from Mrs. Lacks' family to obtain the sample by either the physician who took the sample nor Dr Gey, the guy who propagated the cell line. Mrs. Lacks has been described as "a black woman whose body had been exploited by white scientists".

Frankly, I get Dr Gey's situation; you get samples for your experiment, you don't tend to question too much. After all, they are hard to come by. These days, what with university and hospital ethics committee having a voice in how you conduct your research, these sort of things are in the past. As the idea for informed consent evolve and people began to understand and assert their rights, no one will blindly sign forms just because someone in a white coat told them to do so.

Then again, may be not. Ask anyone who has to collect human samples for their research experiments.

But I digress.

The issue here is her tissue (notice the alliteration? I'm kinda proud of it XD). Although Dr Gey received no monetary rewards from the development of the cell lines (or so it stated), but there have been hundreds of inventions and innovations that had come about thanks to these ever multiplying immortalised cells. If the decendants of Arthur Conan Doyle could still dictate the way the source material of Sherlock Holmes is treated (and getting paid gobs of money for the right), why shouldn't her children, who are also not well-off and presumably struggling, benefit from the companies who have made millions out of the cells that had killed their mother?

*ponders*

Saturday, January 30, 2010

Unplugged

When it comes to making medical decisions, things are rarely black and white. There are laws regulating actions and also people's opinion to be considered before anything is done.

When I first read about baby Isaiah May, I was thinking: perhaps pulling the plug on a child who has permanent brain damage isn't a bad thing. But you gotta consider the parents; you may say that they are young and could have other children, but this is their child one is considering to allow to die. How many parents can make the decision to end their offspring this way when the baby has shown so much in the face of negativity?

Then there will be voices saying, "Who'll be footing the bill for the baby to be placed on ventilation? Should you spend precious resources on a child who may not survive his first year or on another baby who has got a better fighting chance?" It appears that the young parents are not financially well-off; most likely the government is paying for the treatment. Does this mean that children of poor people have less value than the children of those who can afford the care?

Decisions, decisions. I wouldn't want to be the hospital administrator in this issue.

However, I was appalled that the doctors allowed the mother to suffer 40 freakin' hours of labour . It's a miracle she still had the energy to push. Which also brings to mind, why on earth wasn't the foetus monitored for distress? Surely the foetus would have exhibited some kind of distress with the umbilical cord strangling him while he's trying to make way for the exit? When my sister was in labour for barely 4 hours, they monitored the foetus constantly and when the foetus showed signs of distress, she was immediately whisked into the operation theatre for a Caesarean procedure.

On top of that, isn't it common procedure for the foetus to be extracted via C-section when the labour is prolonged? Surely one of the biggest reason the labour took so long is because the baby is choking on the cord and couldn't get out. Is anyone looking at this hideous oversight / poor policy in the labour ward that caused the poor child and his parents so much suffering?

Wednesday, January 27, 2010

Why can't we have it all?

The happy fog induced by marijuana is nothing but a fond memory if Sanofi-Aventis has their way. They are working on an endocannabinoid receptor blocker that has shown interesting result in reducing the blood sugar of diabetics who have poor sugar control. The numbers look really good; it also helps that the drug also improves the patient's lipid profile (better triglyceride, HDL, LDL levels) and most importantly: reduces the waistline.

Unfortunately, if you are depressed to begin with, you may feel suicidal.

So yeah, trimmer waistline may correspond with a greater need for Xanax.

I'll watch American Idol if ...

... this is true.

Breaking News - New judge to replace Paula Abdul on Idol
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Saturday, January 23, 2010

Who needs enemies when ...

Got anyone in your life that makes you feel this way?

REGRET
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*sigh*

Numb3rs in life

Maths is the language of the universe. All digits are the same regardless whether you are in Tirana, Timur Leste, Timbuktu, Tasmania, or Tenochtitlan. They tell the same stories, uniting facts and figures, giving intrinsic value to things and data.

But like any language, some things get lost in translation. This usually happens, thanks to the spuriousness of the science called statistics where standard deviations may be deviants of the worst degree.

And the next thing we know, shit like subprime mortgage hits the fan. Why? Because the statisticians made the numbers look good.

Where is Charlie Eppes when you need him?

Wednesday, January 20, 2010

Jaw dropper

Cowboys don't really do it for me. But these guys?

OMG.

*topples*



If these guys ever make it to our shores, Ima empty the piggy bank to go and watch.

*licks lips*

And no Brokeback quips, ok? Let me have some fantasy of straight men who can move.

Monday, January 18, 2010

Take a chance on me ...

This short film was screened at Cannes and won last year. I love how much was told in such a short period and how creatively it was done.

Sweet and lovely.

Sunday, January 17, 2010

Who's your daddy?

Depending on your intonation and inflection, the phrase above could be either:

a) an innocent inquiry, or
b) an invitation to violence, or
c) taunting someone after pwning to the nth degree.

In the common parlance, (c) is commonly the favoured answer. But option (a) can be quite the booby trap, snapping steel-trap jaws on the unwary.

Sperm donation has made possible many infertile couples to have children. It has also allowed single women to have biological children as well. Once upon a time, sperm donations were relatively anonymous: all a donor had to do is fill up a questionnaire regarding his health and education and off he goes produce the desired fluid in privacy (with the help of a handy visual aid or two). Most fertility centre pay these men for their time (and specimen!), making it particularly an attractive way for college-age men to afford the weekend beer.

As more awareness of the ethical considerations of this issue surface, more stringent regulations are put into place to control assisted reproduction technology. Many countries, particularly in Europe and United States are no longer allowing anonymous donation, driving down the number of sperm donors. Lack of anonymity renders them vulnerable to unwanted contact with their offspring and even potential financial assistance demand. There are a number of donors who are categorised as open donors; i.e. they are alright to being approached by their offspring after they reached 18. However, their numbers are relatively small.

So what is your obligation to your gamete? Your donation has made a child, a person of his/her own right. Someone who is genetically linked to you. Whether or not you have any kind of relationship with the mother, or even know who she is, the child is half yours; 50% of the child's chromosomes come from you. That in itself means that you have a moral obligation to play a role in the child's life.

Women who get pregnant (either planned pregnancy or otherwise) are expected to want their children and to take care of them until they mature. Therefore women are expected to bear the burden of their fecundity by default. So why is it women who opted to terminate their pregnancy (without it being a health risk) are pilloried? Why are men exempted from this?

Many religions frown upon gamete donation. In muddies the relationship and lineage of inheritance. A number of people conceived via gamete donation has decided to look for their biological parent, hoping to fulfill some kind of emptiness from the lack of knowledge of their familial history. And as more women donate their eggs, there is the possibility that one day we will hear of people looking for their donor mothers.

By the way, if you think that sperm donation is only for the heathenish West, think again. We also have them in Malaysia. *snicker*